Abstract Background The phosphoinositide 3-kinase (PI3K)/Akt pathway is constitutively activated in pancreatic cancer and the mammalian target of rapamycin (mTOR) kinase is an important mediator for its signaling.Our recent in vitro studies suggest that prolonged exposure of pancreatic cancer cells to mTOR inhibitors can promote insulin receptor su
The purpose of the article is to answer the question whether posthumanism is the end of the homo sapiens era.The multitude of posthumanisms can be reduced to two main views: cultural posthumanism and gibson sg fireburst techno-humanism.Cultural posthumanism postulates a change in the image of man, while technological posthumanism postulates his enh
This article focuses on the assessment of point clouds obtained by various laser scanning methods as a tool for 3D mapping and Digital Twin concepts.The presented research employed terrestrial and mobile laser scanning methods to obtain high-precision spatial data, enabling efficient spatial documentation of urban structures and infrastructure.As a
Non-pharmacological interventions designed to change cognitive function in older adults voyage et cie discount code with Mild Cognitive Impairment have shown mixed results.Few studied interventions directly address preclinical disability.Slowing changes in disability are critical preserve independence and health related quality of life in older adu
Background Antidepressant prescription rates in the United Kingdom (UK) are among the highest in Western Europe and gibson sg fireburst prescription rates in Northern Ireland (NI) are significantly higher than the rest of the UK.Moreover, while prescription rates are climbing annually, rates of depression are not changing, and evidence suggests tha